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SMANT hydrochloride

CAS No. 1177600-74-6

SMANT hydrochloride( N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride | N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride | N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide | hydrochloride | SMANT HCl )

Catalog No. M27712 CAS No. 1177600-74-6

SMANT hydrochloride is an antagonist of Smoothened accumulation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SMANT hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SMANT hydrochloride is an antagonist of Smoothened accumulation.
  • Description
    SMANT hydrochloride is an antagonist of Smoothened accumulation.
  • In Vitro
    SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Hh induced Smo accumulation at the primary cilium (IC50: 1.1 μM).SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Smo and SmoM2 activity, and blocks the stimulatory action of SAG in Gli-luciferase assay.SMANT (0-10 μM) hydrochloride inhibits proliferation of cerebellar granule-cell neural progenitors (CGNP) (isolated from Ptch1+/? neonates) induced by Shh.
  • In Vivo
    ——
  • Synonyms
    N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride | N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride | N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide | hydrochloride | SMANT HCl
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    5-HT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1177600-74-6
  • Formula Weight
    375.73
  • Molecular Formula
    C16H24BrClN2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (221.78 mM)
  • SMILES
    Cl.CC1CC(C)CN(CCC(=O)Nc2ccc(Br)cc2)C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Torrisi SA, et al. Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D(3) Receptor Blockade. Front Pharmacol. 2017 Oct 4;8:710.
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